A Dissipative Approach to the Identification of Biochemical Reaction Networks
نویسندگان
چکیده
Estimation of kinetic parameters is a key step in modelling biochemical reaction networks as, often, their direct estimation is expensive, time-consuming or even infeasible. This article proposes a parameter estimation procedure, which explicitly takes into account the model structure of the biological systems. The convergence is guaranteed using a dissipativity argument and a coordinate transformation yielding a parameter-free system description. The application to a basic enzyme kinetic model illustrates the proposed methodology.
منابع مشابه
Numerical modeling for nonlinear biochemical reaction networks
Nowadays, numerical models have great importance in every field of science, especially for solving the nonlinear differential equations, partial differential equations, biochemical reactions, etc. The total time evolution of the reactant concentrations in the basic enzyme-substrate reaction is simulated by the Runge-Kutta of order four (RK4) and by nonstandard finite difference (NSFD) method. A...
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